The biology and functional importance of MAIT cells
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
HIV infection: epidemiology, pathogenesis, treatment, and prevention
HIV prevalence is increasing worldwide because people on antiretroviral therapy are living
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …
longer, although new infections decreased from 3· 3 million in 2002, to 2· 3 million in 2012 …
MAIT cell activation and dynamics associated with COVID-19 disease severity
T Parrot, JB Gorin, A Ponzetta, KT Maleki… - Science …, 2020 - science.org
Severe COVID-19 is characterized by excessive inflammation of the lower airways. The
balance of protective versus pathological immune responses in COVID-19 is incompletely …
balance of protective versus pathological immune responses in COVID-19 is incompletely …
Mucosal-associated invariant T cells and disease
A Toubal, I Nel, S Lotersztajn, A Lehuen - Nature Reviews Immunology, 2019 - nature.com
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
MAIT cells are activated during human viral infections
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
Intracellular pathogens: host immunity and microbial persistence strategies
A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …
are ranked as the second leading cause of death worldwide by the World Health …
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …
CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner
CD 161++ CD 8+ T cells represent a novel subset that is dominated in adult peripheral
blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a …
blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a …
[HTML][HTML] MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …