Whole-genome duplication in teleost fishes and its evolutionary consequences
Whole-genome duplication (WGD) events have shaped the history of many evolutionary
lineages. One such duplication has been implicated in the evolution of teleost fishes, by far …
lineages. One such duplication has been implicated in the evolution of teleost fishes, by far …
Gene duplication as a mechanism of genomic adaptation to a changing environment
FA Kondrashov - Proceedings of the Royal Society B …, 2012 - royalsocietypublishing.org
A subject of extensive study in evolutionary theory has been the issue of how neutral,
redundant copies can be maintained in the genome for long periods of time. Concurrently …
redundant copies can be maintained in the genome for long periods of time. Concurrently …
The multiple fates of gene duplications: deletion, hypofunctionalization, subfunctionalization, neofunctionalization, dosage balance constraints, and neutral variation
Gene duplications have long been recognized as a contributor to the evolution of genes with
new functions. Multiple copies of genes can result from tandem duplication, from …
new functions. Multiple copies of genes can result from tandem duplication, from …
Insights into land plant evolution garnered from the Marchantia polymorpha genome
The evolution of land flora transformed the terrestrial environment. Land plants evolved from
an ancestral charophycean alga from which they inherited developmental, biochemical, and …
an ancestral charophycean alga from which they inherited developmental, biochemical, and …
[HTML][HTML] Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources
Quantitative views of cellular functions require precise measures of rates of biomolecule
production, especially proteins—the direct effectors of biological processes. Here, we …
production, especially proteins—the direct effectors of biological processes. Here, we …
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
S Singla, LK Iwamoto-Stohl, M Zhu… - Nature …, 2020 - nature.com
The high incidence of aneuploidy in the embryo is considered the principal cause for low
human fecundity. However, the prevalence of aneuploidy dramatically declines as …
human fecundity. However, the prevalence of aneuploidy dramatically declines as …
[HTML][HTML] Genome sequencing and population genomic analyses provide insights into the adaptive landscape of silver birch
Silver birch (Betula pendula) is a pioneer boreal tree that can be induced to flower within 1
year. Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make …
year. Its rapid life cycle, small (440-Mb) genome, and advanced germplasm resources make …
The evolution of gene duplications: classifying and distinguishing between models
Gene duplications and their subsequent divergence play an important part in the evolution
of novel gene functions. Several models for the emergence, maintenance and evolution of …
of novel gene functions. Several models for the emergence, maintenance and evolution of …
[HTML][HTML] Principles of cancer therapy: oncogene and non-oncogene addiction
Cancer is a complex collection of distinct genetic diseases united by common hallmarks.
Here, we expand upon the classic hallmarks to include the stress phenotypes of …
Here, we expand upon the classic hallmarks to include the stress phenotypes of …
The evolutionary significance of ancient genome duplications
Many organisms are currently polyploid, or have a polyploid ancestry and now have
secondarily'diploidized'genomes. This finding is surprising because retained whole-genome …
secondarily'diploidized'genomes. This finding is surprising because retained whole-genome …