Since the transition from water to land, maintaining water balance has been a key challenge
for terrestrial arthropods. We explore factors that allow terrestrial arthropods to survive within …

Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

Maintenance of renal function and fluid transport are essential for vertebrates and
invertebrates to adapt to physiological and pathological challenges. Human patients with …

Recent advances in single-cell sequencing provide a unique opportunity to gain novel
insights into the diversity, lineage, and functions of cell types constituting a tissue/organ …

Water is essential to life. Terrestrial insects lose water by evaporation from the body surface
and respiratory surfaces, as well as in the excretory products, posing a challenge made …

Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent
pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic …

Transporting epithelia provide a protective barrier against pathogenic insults while allowing
the controlled exchange of ions, solutes and water with the external environment. In …

Precise coupling between cellular physiology and metabolism is emerging as a vital
relationship underpinning tissue health and longevity. Nevertheless, functional-metabolic …

Ticks are blood-feeding arthropods that require heme for their successful reproduction.
During feeding they also acquire pathogens that are subsequently transmitted to humans …

Tenebrionid beetles have been highly successful in colonising environments where water is
scarce, underpinned by their unique osmoregulatory adaptations. These include a …