Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …
excessive and chronic inflammatory responses can lead to deleterious effects involving …
What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
The neuropeptide substance P (SP) plays an important role in neurodegenerative disorders,
among which Parkinson's disease (PD). In the present work we have reviewed the …
among which Parkinson's disease (PD). In the present work we have reviewed the …
Novel trajectories of the NK1R antagonist aprepitant in rotenone-induced Parkinsonism-like symptoms in rats: Involvement of ERK5/KLF4/p62/Nrf2 signaling axis
AM El-Deeb, AF Mohamed, MF El-Yamany… - Chemico-Biological …, 2023 - Elsevier
Regulation of the interplay between autophagy and oxidative stress is vital in maintaining
neuronal homeostasis during neurotoxicity. The interesting involvement of NK1 receptor …
neuronal homeostasis during neurotoxicity. The interesting involvement of NK1 receptor …
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease
Neuroinflammation and blood brain barrier (BBB) dysfunction have been implicated in the
pathogenesis of Parkinson's disease (PD). The neuropeptide substance P (SP) is an …
pathogenesis of Parkinson's disease (PD). The neuropeptide substance P (SP) is an …
Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death …
M Li, X Zhong, WT Xu - Cell Cycle, 2022 - Taylor & Francis
ABSTRACT NOD-like receptor family pyrin domain containing three (NLRP3) inflammasome-
mediated pyroptotic cell death and inflammation contribute to the pathogenesis of bronchial …
mediated pyroptotic cell death and inflammation contribute to the pathogenesis of bronchial …
Using gelatin nanoparticle mediated intranasal delivery of neuropeptide substance P to enhance neuro-recovery in hemiparkinsonian rats
YZ Zhao, RR **, W Yang, Q **ang, WZ Yu, Q Lin… - PloS one, 2016 - journals.plos.org
Purpose Intranasal administration of phospholipid-based gelatin nanoparticles (GNP) was
prepared to investigate the neuro-recovery effects of neuropeptide Substance P (SP) on …
prepared to investigate the neuro-recovery effects of neuropeptide Substance P (SP) on …
Substance P and antagonists of the neurokinin-1 receptor in neuroinflammation associated with infectious and neurodegenerative diseases of the central nervous …
AN Martinez, MT Philipp - Journal of neurology & …, 2016 - pmc.ncbi.nlm.nih.gov
This review addresses the role that substance P (SP) and its preferred receptor neurokinin-1
(NK1R) play in neuroinflammation associated with select bacterial, viral, parasitic, and …
(NK1R) play in neuroinflammation associated with select bacterial, viral, parasitic, and …
N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats
Neuroinflammation plays an important role in the pathophysiology of Alzheimer's disease.
Neurokinin substance P is a key mediator which modulates neuroinflammation through …
Neurokinin substance P is a key mediator which modulates neuroinflammation through …
[HTML][HTML] Demystifying the neuroprotective role of neuropeptides in Parkinson's disease: A newfangled and eloquent therapeutic perspective
T Behl, P Madaan, A Sehgal, S Singh… - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) refers to one of the eminently grievous, preponderant, tortuous
nerve-cell-devastating ailments that markedly impacts the dopaminergic (DArgic) nerve cells …
nerve-cell-devastating ailments that markedly impacts the dopaminergic (DArgic) nerve cells …
N‐acetyl‐l‐tryptophan, but not N‐acetyl‐d‐tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis
AC Sirianni, J Jiang, J Zeng, LL Mao… - Journal of …, 2015 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss. Evidence suggests that mitochondrial dysfunction …
progressive motor neuron loss. Evidence suggests that mitochondrial dysfunction …