Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants

M Grønbæk-Thygesen, V Voutsinos… - Nature …, 2024 - nature.com
Unstable proteins are prone to form non-native interactions with other proteins and thereby
may become toxic. To mitigate this, destabilized proteins are targeted by the protein quality …

Integrated multiplexed assays of variant effect reveal determinants of catechol-O-methyltransferase gene expression

I Hoskins, S Rao, C Tante, C Cenik - Molecular Systems Biology, 2024 - embopress.org
Multiplexed assays of variant effect are powerful methods to profile the consequences of
rare variants on gene expression and organismal fitness. Yet, few studies have integrated …

[HTML][HTML] Integrated multiplexed assays of variant effect reveal cis-regulatory determinants of catechol-O-methyltransferase gene expression

I Hoskins, S Rao, C Tante, C Cenik - bioRxiv, 2023 - ncbi.nlm.nih.gov
Multiplexed assays of variant effect are powerful methods to profile the consequences of
rare variants on gene expression and organismal fitness. Yet, few studies have integrated …