Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Alpha-synuclein oligomers: a new hope
Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …
main pathological drivers in the disease, although it remains unclear how this protein elicits …
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes
Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Oligomeric species populated during the aggregation process of α-synuclein have been
linked to neuronal impairment in Parkinson's disease and related neurodegenerative …
linked to neuronal impairment in Parkinson's disease and related neurodegenerative …
Widespread occurrence of the droplet state of proteins in the human proteome
A wide range of proteins have been reported to condensate into a dense liquid phase,
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus,
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …
[HTML][HTML] Amyloid structures: much more than just a cross-β fold
Highlights•New structures have shown that there is a remarkable diversity and complexity of
the amyloid fold.•The same sequence forms different amyloid structures in different …
the amyloid fold.•The same sequence forms different amyloid structures in different …
Implications of peptide assemblies in amyloid diseases
Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …
quality of life of millions worldwide, with profound social and economic implications. Despite …
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
CPA Doherty, SM Ulamec, R Maya-Martinez… - Nature structural & …, 2020 - nature.com
Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology.
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …