One gene can give rise to many functionally distinct proteoforms, each of which has a
characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact …

Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …

Human biology is tightly linked to proteins, yet most measurements do not precisely
determine alternatively spliced sequences or posttranslational modifications. Here, we …

According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Selected reaction monitoring on a triple quadrupole mass spectrometer is currently
experiencing a renaissance within the proteomics community for its, as yet, unparalleled …

A key step in mass spectrometry (MS)-based proteomics is the identification of peptides in
sequence databases by their fragmentation spectra. Here we describe Andromeda, a novel …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …

Today's highly accurate spectra provided by modern tandem mass spectrometers offer
considerable advantages for the analysis of proteomic samples of increased complexity …

While the number and identity of proteins expressed in a single human cell type is currently
unknown, this fundamental question can be addressed by advanced mass spectrometry …