Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

Considerable evidence now implicates elevated expression and/or activity of Src in cancer
development. In cells, endogenous Src is switched from an inactive to an active state by a …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

EGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas,
but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

Caveolae are 50-to 100-nm omega-shaped invaginations of the plasma membrane that
function as regulators of signal transduction. Caveolins are a class of oligomeric structural …

Enterotoxigenic Escherichia coli (ETEC) is a prevalent cause of traveler's diarrhea and infant
mortality in third‐world countries. Heat‐labile enterotoxin (LT) is secreted from ETEC via …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

Lipids are fundamental building blocks of all cells and play important roles in the
pathogenesis of different diseases, including inflammation, autoimmune disease, cancer …