Rodent, large animal and non-human primate models of spinal cord injury

R Nardone, C Florea, Y Höller, F Brigo, V Versace… - Zoology, 2017 - Elsevier
In this narrative review we aimed to assess the usefulness of the different animal models in
identifying injury mechanisms and develo** therapies for humans suffering from spinal …

Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair

ES Rosenzweig, JW McDonald - Current opinion in neurology, 2004 - journals.lww.com
Delayed treatment protocols may extend the window of opportunity for treatment of spinal
cord injury, whereas continued progress in the prevention of secondary cell death will …

Biodegradable and macroporous polylactide implants for cell transplantation: 1. Preparation of macroporous polylactide supports by solid-liquid phase separation

C Schugens, V Maquet, C Grandfils, R Jérôme… - Polymer, 1996 - Elsevier
Freeze-drying of polylactide solutions in 1, 4-dioxane has been studied as a way to produce
microcellular foams. The thermally induced phase separation has been studied in relation to …

A simple and reproducible model of spinal cord injury induced by epidural balloon inflation in the rat

I Vanický, L Urdzíková, K Saganová… - Journal of …, 2001 - liebertpub.com
This paper describes a modification of a balloon-compression technique to produce spinal
cord injury in adult rats. A 2-French Fogarty catheter is inserted into the dorsal epidural …

Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

PE Batchelor, TE Wills, P Skeers, CR Battistuzzo… - PloS one, 2013 - journals.plos.org
Background The use of early decompression in the management of acute spinal cord injury
(SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a …

[PDF][PDF] Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous …

D Bouhy, B Malgrange, S Multon, AL Poirrier… - FASEB journal, 2006 - academia.edu
Macrophages (monocytes/microglia) could play a critical role in central nervous system
repair. We have previously found a synchronism between the regression of spontaneous …

Effects of Schwann cell transplantation in a contusion model of rat spinal cord injury

D Martin, P Robe, R Franzen, P Delree… - Journal of …, 1996 - Wiley Online Library
Cultured Schwann cells were transplanted at various delays into a spinal cord contusion
injury performed at low thoracic level in adult female rats. The Schwann cells were purified …

Spinal cord reconstruction using NeuroGel™ implants and functional recovery after chronic injury

S Woerly, VD Doan, F Evans‐Martin… - Journal of …, 2001 - Wiley Online Library
There is currently a lack of effective ways to achieve functional tissue repair of the
chronically injured spinal cord. We investigated the potential of NeuroGel™, a biocompatible …

Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression …

GA Brook, D Plate, R Franzen, D Martin… - Journal of …, 1998 - Wiley Online Library
Spontaneous cellular reorganisation at the lesion site has been investigated following
massive spinal cord compression injury in adult rats. By 2 days post operation (po) …

Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy

ND Jeffery, PM Smith, A Lakatos, C Ibanez, D Ito… - Spinal cord, 2006 - nature.com
Study design: Review. Objectives: To highlight the value of investigating the effects of
putative therapeutic interventions in clinical spinal cord injury (SCI) in domestic dogs …