Rodent, large animal and non-human primate models of spinal cord injury
In this narrative review we aimed to assess the usefulness of the different animal models in
identifying injury mechanisms and develo** therapies for humans suffering from spinal …
identifying injury mechanisms and develo** therapies for humans suffering from spinal …
Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair
ES Rosenzweig, JW McDonald - Current opinion in neurology, 2004 - journals.lww.com
Delayed treatment protocols may extend the window of opportunity for treatment of spinal
cord injury, whereas continued progress in the prevention of secondary cell death will …
cord injury, whereas continued progress in the prevention of secondary cell death will …
Biodegradable and macroporous polylactide implants for cell transplantation: 1. Preparation of macroporous polylactide supports by solid-liquid phase separation
C Schugens, V Maquet, C Grandfils, R Jérôme… - Polymer, 1996 - Elsevier
Freeze-drying of polylactide solutions in 1, 4-dioxane has been studied as a way to produce
microcellular foams. The thermally induced phase separation has been studied in relation to …
microcellular foams. The thermally induced phase separation has been studied in relation to …
A simple and reproducible model of spinal cord injury induced by epidural balloon inflation in the rat
I Vanický, L Urdzíková, K Saganová… - Journal of …, 2001 - liebertpub.com
This paper describes a modification of a balloon-compression technique to produce spinal
cord injury in adult rats. A 2-French Fogarty catheter is inserted into the dorsal epidural …
cord injury in adult rats. A 2-French Fogarty catheter is inserted into the dorsal epidural …
Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure
PE Batchelor, TE Wills, P Skeers, CR Battistuzzo… - PloS one, 2013 - journals.plos.org
Background The use of early decompression in the management of acute spinal cord injury
(SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a …
(SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a …
[PDF][PDF] Delayed GM-CSF treatment stimulates axonal regeneration and functional recovery in paraplegic rats via an increased BDNF expression by endogenous …
Macrophages (monocytes/microglia) could play a critical role in central nervous system
repair. We have previously found a synchronism between the regression of spontaneous …
repair. We have previously found a synchronism between the regression of spontaneous …
Effects of Schwann cell transplantation in a contusion model of rat spinal cord injury
Cultured Schwann cells were transplanted at various delays into a spinal cord contusion
injury performed at low thoracic level in adult female rats. The Schwann cells were purified …
injury performed at low thoracic level in adult female rats. The Schwann cells were purified …
Spinal cord reconstruction using NeuroGel™ implants and functional recovery after chronic injury
S Woerly, VD Doan, F Evans‐Martin… - Journal of …, 2001 - Wiley Online Library
There is currently a lack of effective ways to achieve functional tissue repair of the
chronically injured spinal cord. We investigated the potential of NeuroGel™, a biocompatible …
chronically injured spinal cord. We investigated the potential of NeuroGel™, a biocompatible …
Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression …
Spontaneous cellular reorganisation at the lesion site has been investigated following
massive spinal cord compression injury in adult rats. By 2 days post operation (po) …
massive spinal cord compression injury in adult rats. By 2 days post operation (po) …
Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy
ND Jeffery, PM Smith, A Lakatos, C Ibanez, D Ito… - Spinal cord, 2006 - nature.com
Study design: Review. Objectives: To highlight the value of investigating the effects of
putative therapeutic interventions in clinical spinal cord injury (SCI) in domestic dogs …
putative therapeutic interventions in clinical spinal cord injury (SCI) in domestic dogs …