DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

Fanconi anemia (FA) is a rare autosomal and X-linked genetic disease characterized by
congenital abnormalities, progressive bone marrow failure (BMF), and increased cancer risk …

Interstrand crosslinks (ICLs) are a highly toxic form of DNA damage. ICLs can interfere with
vital biological processes requiring separation of the two DNA strands, such as replication …

Monoubiquitination and deubiquitination of FANCD2: FANCI heterodimer is central to DNA
repair in a pathway that is defective in the cancer predisposition syndrome Fanconi anemia …

Fanconi anemia (FA) is a rare human genetic disease characterized by bone marrow failure,
cancer predisposition, and genomic instability. It has been known for many years that FA …

The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and
chemotherapy-induced DNA crosslinks, and responds to replication stress,. Genetic …

Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and
increased risk for malignancy. Physical abnormalities, present in approximately 75% of …

FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA
interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified …

Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure,
and cancer predisposition. FA cells are hypersensitive to DNA replicative stress and …