Non-viral vectors for RNA delivery
RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …
Macrocyclic peptides as drug candidates: recent progress and remaining challenges
Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …
high degree of specific binding, and the ability to target protein surfaces traditionally …
Plant antimicrobial peptides: structures, functions, and applications
J Li, S Hu, W Jian, C **e, X Yang - Botanical Studies, 2021 - Springer
Antimicrobial peptides (AMPs) are a class of short, usually positively charged polypeptides
that exist in humans, animals, and plants. Considering the increasing number of drug …
that exist in humans, animals, and plants. Considering the increasing number of drug …
Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application
Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …
Cell-penetrating peptides: design strategies beyond primary structure and amphipathicity
Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …
Synthesis of side-chain modified polypeptides
Proteins have long fascinated scientists since their complex sequences and diversity of
chemical functionality can lead to structurally defined folded chains with highly specific …
chemical functionality can lead to structurally defined folded chains with highly specific …
Functional biodegradable polymers via ring-opening polymerization of monomers without protective groups
Biodegradable polymers are of current interest and chemical functionality in such materials
is often demanded in advanced biomedical applications. Functional groups often are not …
is often demanded in advanced biomedical applications. Functional groups often are not …
Fluorinated α-helical polypeptides synchronize mucus permeation and cell penetration toward highly efficient pulmonary siRNA delivery against acute lung injury
The mucus layer and cell membrane are two major barriers against pulmonary siRNA
delivery. Commonly used polycationic gene vectors can hardly penetrate the mucus layer …
delivery. Commonly used polycationic gene vectors can hardly penetrate the mucus layer …
Secondary structures of synthetic polypeptide polymers
Synthetic peptide-based polymers represent a unique class of macromolecules able to
mimic the properties of natural proteins in materials sciences since (1) they present the …
mimic the properties of natural proteins in materials sciences since (1) they present the …
Cellular uptake of substrate-initiated cell-penetrating poly (disulfide) s
Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …
introduced as general transporters for the covalent delivery of unmodified substrates of free …