The MiT‐TFE family of basic helix‐loop‐helix leucine‐zipper transcription factors includes
four members: TFEB, TFE 3, TFEC, and MITF. Originally described as oncogenes, these …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

Background & Aims Defects in lysosome function and autophagy contribute to the
pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol …

Lysosomes are the major cellular site for clearance of defective organelles and digestion of
internalized material. Demand on lysosomal capacity can vary greatly, and lysosomal …

The discovery of a gene network regulating lysosomal biogenesis and its transcriptional
regulator transcription factor EB (TFEB) revealed that cells monitor lysosomal function and …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular
processes, such as lysosomal biogenesis and autophagy. The subcellular localization and …

Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …