Highly efficient modeling and optimization of neural fiber responses to electrical stimulation

MA Hussain, WM Grill, NA Pelot - Nature Communications, 2024 - nature.com
Peripheral neuromodulation has emerged as a powerful modality for controlling
physiological functions and treating a variety of medical conditions including chronic pain …

[HTML][HTML] Temporal interference stimulation targets deep brain regions by modulating neural oscillations

Z Esmaeilpour, G Kronberg, D Reato, LC Parra… - Brain Stimulation, 2021 - Elsevier
Background Temporal interference (TI) stimulation of the brain generates amplitude-
modulated electric fields oscillating in the kHz range with the goal of non-invasive targeted …

[HTML][HTML] Kilohertz-frequency stimulation of the nervous system: A review of underlying mechanisms

C Neudorfer, CT Chow, A Boutet, A Loh, J Germann… - Brain stimulation, 2021 - Elsevier
Background Electrical stimulation in the kilohertz-frequency range has gained interest in the
field of neuroscience. The mechanisms underlying stimulation in this frequency range …

Simulation study of intermittent axonal block and desynchronization effect induced by high-frequency stimulation of electrical pulses

Z Guo, Z Feng, Y Wang, X Wei - Frontiers in neuroscience, 2018 - frontiersin.org
Deep brain stimulation (DBS) has been successfully used in treating neural disorders in
brain, such as Parkinson's disease and epilepsy. However, the precise mechanisms of DBS …

High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction

Z Feng, Z Wang, Z Guo, W Zhou, Z Cai, DM Durand - Brain research, 2017 - Elsevier
Deep brain stimulation (DBS) is effective for treating neurological disorders in clinic.
However, the therapeutic mechanisms of high-frequency stimulation (HFS) of DBS have not …

Bio-heat model of kilohertz-frequency deep brain stimulation increases brain tissue temperature

N Khadka, IE Harmsen, AM Lozano… - … : Technology at the Neural …, 2020 - Elsevier
Objectives Early clinical trials suggest that deep brain stimulation at kilohertz frequencies
(10 kHz-DBS) may be effective in improving motor symptoms in patients with movement …

Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics

CR Ravasio, K Kondabolu, S Zhou, E Lowet… - Communications …, 2025 - nature.com
Intracranial electrical kilohertz stimulation has recently been shown to achieve similar
therapeutic benefit as conventional frequencies around 140 Hz. However, it is unknown how …

A network model of local field potential activity in essential tremor and the impact of deep brain stimulation

N Yousif, M Mace, N Pavese, R Borisyuk… - PLoS computational …, 2017 - journals.plos.org
Essential tremor (ET), a movement disorder characterised by an uncontrollable shaking of
the affected body part, is often professed to be the most common movement disorder …

Asynchronous axonal firing patterns evoked via continuous subthreshold kilohertz stimulation

L Vargas, ED Musselman, WM Grill… - Journal of neural …, 2023 - iopscience.iop.org
Objective. Transcutaneous electrical stimulation of peripheral nerves is a common technique
to assist or rehabilitate impaired muscle activation. However, conventional stimulation …

A neural mass model to predict electrical stimulation evoked responses in human and non-human primate brain

I Basu, B Crocker, K Farnes… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Deep brain stimulation (DBS) is a valuable tool for ameliorating drug resistant
pathologies such as movement disorders and epilepsy. DBS is also being considered for …