Mechanisms, applications, and challenges of insect RNA interference

KY Zhu, SR Palli - Annual review of entomology, 2020 - annualreviews.org
The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was
discovered in nematodes and found to function in most living organisms. RNAi has been …

Prospects, challenges and current status of RNAi through insect feeding

N Kunte, E McGraw, S Bell, D Held… - Pest management …, 2020 - Wiley Online Library
RNA interference is a phenomenon in which the introduction of double‐stranded RNA
(dsRNA) into cells triggers the degradation of the complementary messenger RNA in a …

Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA

J Chen, Y Peng, H Zhang, K Wang, C Zhao, G Zhu… - RNA biology, 2021 - Taylor & Francis
RNAi is a potent technique for the knockdown of target genes. However, its potential off-
target effects limit the widespread applications in both reverse genetic analysis and genetic …

Next generation dsRNA-based insect control: Success so far and challenges

RB Nitnavare, J Bhattacharya, S Singh… - Frontiers in Plant …, 2021 - frontiersin.org
RNA interference (RNAi) is a method of gene silencing where dsRNA is digested into small
interfering RNA (siRNA) in the presence of enzymes. These siRNAs then target homologous …

Application progress of plant-mediated RNAi in pest control

X Li, X Liu, W Lu, X Yin, S An - Frontiers in Bioengineering and …, 2022 - frontiersin.org
RNA interference (RNAi)-based biopesticides are novel biologic products, developed using
RNAi principles. They are engineered to target genes of agricultural diseases, insects, and …

Risk assessment of RNAi-based pesticides to non-target organisms: evaluating the effects of sequence similarity in the parasitoid wasp Telenomus podisi

NL Castellanos, G Smagghe, CNT Taning… - Science of the Total …, 2022 - Elsevier
RNA interference (RNAi)-based pesticides are promising novel pest management products
that might reduce environmental impacts compared to other pesticides. Their sequence …

Functional analysis of CYP6AE68, a cytochrome P450 gene associated with indoxacarb resistance in Spodoptera litura (Lepidoptera: Noctuidae)

WT Hou, C Staehelin, MEA Elzaki, M Hafeez… - Pesticide biochemistry …, 2021 - Elsevier
Spodoptera litura (Fabricius) is a widely distributed, highly polyphagous pest that can cause
severe damage to a variety of economically important crops. Various populations have …

Transcript level and sequence matching are key determinants of off-target effects in RNAi

J Chen, CW Sheng, Y Peng, K Wang… - Journal of Agricultural …, 2023 - ACS Publications
Double-stranded RNA (dsRNA) pesticides, those based on RNA interference (RNAi)
technology utilizing dsRNA, have shown potential for pest control. However, the off-target …

Susceptibility of mountain pine beetle (Dendroctonus ponderosae Hopkins) to gene silencing through RNAi provides potential as a novel management tool

BR Kyre, BJ Bentz, LK Rieske - Forest Ecology and Management, 2020 - Elsevier
The mountain pine beetle (MPB), Dendroctonus ponderosae, is an eruptive endemic forest
pest that is undergoing substantial range expansion in response to recent climatic changes …

Tritrophic metabolism of plant chemical defenses and its effects on herbivore and predator performance

R Sun, X Jiang, M Reichelt, J Gershenzon, SS Pandit… - Elife, 2019 - elifesciences.org
Insect herbivores are frequently reported to metabolize plant defense compounds, but the
physiological and ecological consequences are not fully understood. It has rarely been …