Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and
Takeda G protein-coupled receptor 5 (TGR5) is a member of this family. As a membrane …

Incomplete understanding of how hepatosteatosis transitions to fibrotic non-alcoholic
steatohepatitis (NASH) has limited therapeutic options. Two molecules that are elevated in …

The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

Alveolar macrophages (AM) play a central role in initiation and resolution of lung
inflammation, but the integration of these opposing core functions is poorly understood. AM …

Cholesterol is an essential component of plasma membrane and precursor of biological
active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis …

Oxysterols are derivatives of cholesterol and an important regulator of cholesterol
metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X …

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids
and pigmented glia (ALSP). Previous studies in the Csf1r+/− mouse model of ALSP …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …