Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China
L Yang, Z Wang - European journal of medicinal chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
Recent advances in SARS-CoV-2 main protease inhibitors: from nirmatrelvir to future perspectives
A Citarella, A Dimasi, D Moi, D Passarella, A Scala… - Biomolecules, 2023 - mdpi.com
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
[HTML][HTML] Synthesis of new organoselenium-based succinanilic and maleanilic derivatives and in silico studies as possible SARS-CoV-2 main protease inhibitors
Herein we report the synthesis of organic selenide-based maleanilic and succinanilic acids
in good yields (up to 95%). Their structural identities were elucidated by spectroscopic …
in good yields (up to 95%). Their structural identities were elucidated by spectroscopic …
Recent advances in covalent drug discovery
D Schaefer, X Cheng - Pharmaceuticals, 2023 - mdpi.com
In spite of the increasing number of biologics license applications, the development of
covalent inhibitors is still a growing field within drug discovery. The successful approval of …
covalent inhibitors is still a growing field within drug discovery. The successful approval of …
Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …
H Mousavi, B Zeynizadeh, M Rimaz - Bioorganic Chemistry, 2023 - Elsevier
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …
On the origins of SARS-CoV-2 main protease inhibitors
YL Janin - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …
High-resolution structure of stem-loop 4 from the 5′-UTR of SARS-CoV-2 solved by solution state NMR
J Vögele, D Hymon, J Martins, J Ferner… - Nucleic Acids …, 2023 - academic.oup.com
We present the high-resolution structure of stem-loop 4 of the 5′-untranslated region
(5_SL4) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
(5_SL4) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
Discovery and mechanism study of SARS-CoV-2 3C-like protease inhibitors with a new reactive group
P Ren, H Li, T Nie, X Jian, C Yu, J Li, H Su… - Journal of Medicinal …, 2023 - ACS Publications
3CLpro is an attractive target for the treatment of COVID-19. Using the scaffold hop**
strategy, we identified a potent inhibitor of 3CLpro (3a) that contains a thiocyanate moiety as …
strategy, we identified a potent inhibitor of 3CLpro (3a) that contains a thiocyanate moiety as …
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review
YQ **ao, J Long, SS Zhang, YY Zhu, SX Gu - Bioorganic Chemistry, 2024 - Elsevier
The COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm
for research & development of effective anti-coronavirus drugs, which are crucial for the …
for research & development of effective anti-coronavirus drugs, which are crucial for the …
Discovery of highly potent covalent SARS-CoV-2 3CLpro inhibitors bearing 2-sulfoxyl-1, 3, 4-oxadiazole scaffold for combating COVID-19
FM Zhang, T Huang, F Wang, GS Zhang, D Liu… - European Journal of …, 2023 - Elsevier
Abstract The coronavirus disease (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a major public health …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a major public health …