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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
L Vande Walle, M Lamkanfi - Nature Reviews Drug Discovery, 2024 - nature.com
Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …
world. As central instigators of the inflammatory response to infection and tissue damage …
The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
HM Blevins, Y Xu, S Biby, S Zhang - Frontiers in aging neuroscience, 2022 - frontiersin.org
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
Cryo-EM structures of the active NLRP3 inflammasome disc
L **ao, VG Magupalli, H Wu - Nature, 2023 - nature.com
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
The NLRP3 inflammasome: contributions to inflammation-related diseases
Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …
innate immune responses by activating caspase-1 and the inflammatory cytokines …
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
A Pandeya, TD Kanneganti - Trends in molecular medicine, 2024 - cell.com
The innate immune system initiates cell death pathways in response to pathogens and
cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis …
cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis …
How location and cellular signaling combine to activate the NLRP3 inflammasome
A Akbal, A Dernst, M Lovotti, MSJ Mangan… - Cellular & molecular …, 2022 - nature.com
Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
CL Evavold, I Hafner-Bratkovič, P Devant, JM D'Andrea… - Cell, 2021 - cell.com
The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …
Signaling pathways of chronic kidney diseases, implications for therapeutics
Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …
[HTML][HTML] Pharmacological inhibition of the NLRP3 inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction
Q Ma - Pharmacological reviews, 2023 - Elsevier
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …