Brownian dynamics simulations of biological molecules

GA Huber, JA McCammon - Trends in chemistry, 2019 - cell.com
Brownian dynamics (BD) is a technique for carrying out computer simulations of physical
systems that are driven by thermal fluctuations. Biological systems at the macromolecular …

Protein interactions with negatively charged inorganic surfaces

K Kubiak-Ossowska, B Jachimska… - Current opinion in …, 2019 - Elsevier
Protein adsorption on charged inorganic solid materials has recently attracted enormous
interest owing to its various possible applications, including drug delivery and biomaterial …

Photonic-plasmonic hybrid single-molecule nanosensor measures the effect of fluorescent labels on DNA-protein dynamics

F Liang, Y Guo, S Hou, Q Quan - Science advances, 2017 - science.org
Current methods to study molecular interactions require labeling the subject molecules with
fluorescent reporters. However, the effect of the fluorescent reporters on molecular dynamics …

Time Evolution of Ultrasmall Gold Nanoparticle–Protein Interactions

AF Lima, VS Guido, N Mina, RJS Torquato, AA Sousa - Langmuir, 2023 - ACS Publications
To date, much effort has been devoted toward the study of protein corona formation onto
large gold nanoparticles (GNPs). However, the protein corona concept breaks down for …

Adsorption-Driven Deformation and Footprints of the RBD Proteins in SARS-CoV-2 Variants on Biological and Inanimate Surfaces

AM Bosch, HV Guzman, R Pérez - Journal of Chemical …, 2024 - ACS Publications
Respiratory viruses, carried through airborne microdroplets, frequently adhere to surfaces,
including plastics and metals. However, our understanding of the interactions between …

pH-Induced reorientation of cytochrome c on silica nanoparticles

J Meissner, Y Wu, J Jestin, WA Shelton, GH Findenegg… - Soft Matter, 2019 - pubs.rsc.org
The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied
in a wide pH range by combining small-angle neutron scattering, adsorption measurements …

[HTML][HTML] Small, smaller, smallest: Miniaturization of chromatographic process development

TC Silva, M Eppink, M Ottens - Journal of Chromatography A, 2022 - Elsevier
Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal
antibodies (mAb) are one of the most widely used therapeutic proteins and are important for …

Controlling experimental parameters to improve characterization of biomaterial fouling

AH Jesmer, RG Wylie - Frontiers in Chemistry, 2020 - frontiersin.org
Uncontrolled protein adsorption and cell binding to biomaterial surfaces may lead to
degradation, implant failure, infection, and deleterious inflammatory and immune responses …

Protein-Rich Rafts in Hybrid Polymer/Lipid Giant Unilamellar Vesicles

N Otrin, L Otrin, C Bednarz, TK Träger… - …, 2024 - ACS Publications
Considerable attention has been dedicated to lipid rafts due to their importance in numerous
cell functions such as membrane trafficking, polarization, and signaling. Next to studies in …

Dominant albumin–surface interactions under independent control of surface charge and wettability

S Guo, D Pranantyo, ET Kang, XJ Loh, X Zhu… - Langmuir, 2018 - ACS Publications
Understanding protein adsorption behaviors on solid surfaces constitutes an important step
toward development of efficacious and biocompatible medical devices. Both surface charge …