T-cell activation is a critical event in the organization of effective cellular and humoral
immune responses. Activated T cells are essential for provision of T-cell help, promoting the …

Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective
adoptive cellular immunotherapy for the treatment of a number of cancers. The …

Infusion of either embryonic or mesenchymal stem cells prolongs the survival of organ
transplants derived from stem cell donors and prevents graft-versus-host-disease (GVHD) …

In this study, we investigated whether mesenchymal stem cells (MSC) had
immunomodulatory properties in solid organ allotransplantation, using a semiallogeneic …

Immune regulatory CD4+ CD25+ cells play a vital role in the induction and maintenance of
self-tolerance and are essential for T cell homeostasis and the prevention of autoimmunity …

Since the introduction of organ transplantation into medical practice, progress and optimism
have been abundant. Improvements in immunosuppressive drugs and ancillary care have …

Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of
allogeneic bone marrow transplantation (BMT). The immunobiology of acute GVHD is …

Recent progress in deriving human embryonic stem (hES) cells and defining their capacity
to differentiate has inspired hope that they could become a source of replacement cells for …

Mixed Chimerism and Transplant Tolerance: Immunity Skip to Main Content Skip to Main Menu
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We report that disruption of CD154 in nonobese diabetic (NOD) mice abrogates the helper
function of CD4+ CD25− T cells without impairing the regulatory activity of CD4+ CD25+ T …