Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
Gasdermins and pyroptosis in the kidney
EE Elias, B Lyons, DA Muruve - Nature Reviews Nephrology, 2023 - nature.com
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …
Organoid and spheroid tumor models: techniques and applications
Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …
spheroids are different 3D cell culture models that can be cultured with different techniques …
Single-cell atlases: shared and tissue-specific cell types across human organs
The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms
The novel coronavirus (SARS‐CoV‐2) has turned into a life‐threatening pandemic disease
(Covid‐19). About 5% of patients with Covid‐19 have severe symptoms including septic …
(Covid‐19). About 5% of patients with Covid‐19 have severe symptoms including septic …
[HTML][HTML] Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
We have previously provided the first genetic evidence that angiotensin converting enzyme
2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS …
2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS …
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …
prospect of drug screening, disease modelling and the generation of tissue for renal …
Mineralocorticoid receptor antagonists in diabetic kidney disease—Mechanistic and therapeutic effects
Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and
current therapies that limit CKD progression and the development of cardiovascular disease …
current therapies that limit CKD progression and the development of cardiovascular disease …
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …