STAT proteins in cancer: orchestration of metabolism

YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Allogeneic natural killer cell therapy

MM Berrien-Elliott, MT Jacobs, TA Fehniger - Blood, 2023 - ashpublications.org
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …

JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

Mechanisms linking inflammation to insulin resistance

L Chen, R Chen, H Wang… - International journal of …, 2015 - Wiley Online Library
Obesity is now widespread around the world. Obesity‐associated chronic low‐grade
inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a …

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

D Zhou, C Huang, Z Lin, S Zhan, L Kong, C Fang, J Li - Cellular signalling, 2014 - Elsevier
Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals …

Biology of the TAM receptors

G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

Overlap** transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

A Jacobi, NM Tran, W Yan, I Benhar, F Tian, R Schaffer… - Neuron, 2022 - cell.com
Injured neurons in the adult mammalian central nervous system often die and seldom
regenerate axons. To uncover transcriptional pathways that could ameliorate these …

Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance

JJ Pestka - Archives of toxicology, 2010 - Springer
The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn
following infestation by the fungus Fusarium in the field and during storage. Colloquially …

Role of STAT3 in cancer metastasis and translational advances

MZ Kamran, P Patil, RP Gude - BioMed research international, 2013 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic
transcription factor, originally discovered as a transducer of signal from cell surface …

The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy

M Garg, MK Shanmugam, V Bhardwaj… - Medicinal research …, 2021 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …