STAT proteins in cancer: orchestration of metabolism
YJ Li, C Zhang, A Martincuks, A Herrmann… - Nature reviews Cancer, 2023 - nature.com
Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …
cancer, from tumour initiation through disease progression and therapy resistance, requires …
Allogeneic natural killer cell therapy
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …
JAK-STAT pathway inhibition and their implications in COVID-19 therapy
S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …
Mechanisms linking inflammation to insulin resistance
L Chen, R Chen, H Wang… - International journal of …, 2015 - Wiley Online Library
Obesity is now widespread around the world. Obesity‐associated chronic low‐grade
inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a …
inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a …
Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways
D Zhou, C Huang, Z Lin, S Zhan, L Kong, C Fang, J Li - Cellular signalling, 2014 - Elsevier
Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals …
phenotypically/functionally dynamic switch in response to the microenvironment signals …
Biology of the TAM receptors
G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …
kinases, in that as a group they play no essential role in embryonic development. Instead …
Overlap** transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells
Injured neurons in the adult mammalian central nervous system often die and seldom
regenerate axons. To uncover transcriptional pathways that could ameliorate these …
regenerate axons. To uncover transcriptional pathways that could ameliorate these …
Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
JJ Pestka - Archives of toxicology, 2010 - Springer
The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn
following infestation by the fungus Fusarium in the field and during storage. Colloquially …
following infestation by the fungus Fusarium in the field and during storage. Colloquially …
Role of STAT3 in cancer metastasis and translational advances
MZ Kamran, P Patil, RP Gude - BioMed research international, 2013 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic
transcription factor, originally discovered as a transducer of signal from cell surface …
transcription factor, originally discovered as a transducer of signal from cell surface …
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy
M Garg, MK Shanmugam, V Bhardwaj… - Medicinal research …, 2021 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …