[HTML][HTML] Immune cell membrane-based biomimetic nanomedicine for treating cancer metastasis

L Zhu, X Yu, T Cao, H Deng, X Tang, Q Lin… - … Pharmaceutica Sinica B, 2023 - Elsevier
Metastasis is the leading cause of cancer-related death. Despite extensive treatment, the
prognosis for patients with metastatic cancer remains poor. In addition to conventional …

[HTML][HTML] Natural killer cell therapy: A new frontier for obesity-associated cancer

E Mylod, J Lysaght, MJ Conroy - Cancer Letters, 2022 - Elsevier
Natural killer (NK) cell infiltration of solid tumours is associated with better outcomes, placing
augmentation of NK cell abundance in tumours as an attractive immunotherapeutic …

Real-time ex vivo monitoring of NK cell migration toward obesity-associated oesophageal adenocarcinoma following modulation of CX3CR1

E Mylod, F O'Connell, NE Donlon, M Davern… - Scientific Reports, 2024 - nature.com
Oesophagogastric adenocarcinomas (OAC) are poor prognosis, obesity-associated cancers
which may benefit from natural killer (NK) cell-based immunotherapies. Cellular …

[HTML][HTML] Harnessing the Power of NK Cell Receptor Engineering as a New Prospect in Cancer Immunotherapy

S Douka, V Papamoschou, M Raimo, E Mastrobattista… - Pharmaceutics, 2024 - mdpi.com
Natural killer (NK) cells have recently gained popularity as an alternative for cancer
immunotherapy. Adoptive cell transfer employing NK cells offers a safer therapeutic option …

The omentum in obesity-associated cancer: A hindrance to effective natural killer cell migration towards tumour which can be overcome by CX3CR1 antagonism

E Mylod, F O'Connell, NE Donlon, C Butler… - Cancers, 2021 - mdpi.com
Simple Summary Oesophagogastric adenocarcinomas (OAC) are cancers of the food pipe
and stomach which have a strong link with obesity. Natural killer (NK) cells are assassins of …

Tumour microenvironment influences response to treatment in oesophageal adenocarcinoma

CJ Belle, JM Lonie, S Brosda, AP Barbour - Frontiers in Immunology, 2023 - frontiersin.org
The poor treatment response of oesophageal adenocarcinoma (OAC) leads to low survival
rates. Its increasing incidence makes finding more effective treatment a priority. Recent …

Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in …

M Davern, C O'Donovan, NE Donlon, E Mylod… - Biomedicines, 2024 - mdpi.com
The presence of an immunosuppressive tumour microenvironment in oesophageal
adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies …

Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses

E Mylod, E McKenna, M Davern, MP Barr… - Clinical and …, 2023 - Springer
The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal
treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti …

[PDF][PDF] NK cell receptor engineering: A New Hope for cancer immunotherapy

B Papamoschou - 2024 - studenttheses.uu.nl
In recent years, Natural killer cells have become a rising alternative for cancer
immunotherapeutic purposes. Their exploitation for adoptive cell transfer (ACT) offers a safer …

Measuring Immune Cell Movement Toward the Soluble Microenvironment of Human Tissues Using a Boyden Chamber-Based Migration Assay

E Mylod, J Lysaght, MJ Conroy - Cancer Cell Culture: Methods and …, 2023 - Springer
Migration assays are used to measure cell movement toward a variety of chemoattractants in
a controlled environment. Here we describe a method for a Boyden chamber-based …