Modelling the endocrine pancreas in health and disease
Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
β-Cell maturation and identity in health and disease
The exponential increase of patients with diabetes mellitus urges for novel therapeutic
strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of …
strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of …
[HTML][HTML] Deciphering early human pancreas development at the single-cell level
Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
diseases. However, the molecular heterogeneity and developmental trajectory of the early …
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion
CA Gonçalves, M Larsen, S Jung, J Stratmann… - Nature …, 2021 - nature.com
Human organogenesis remains relatively unexplored for ethical and practical reasons.
Here, we report the establishment of a single-cell transcriptome atlas of the human fetal …
Here, we report the establishment of a single-cell transcriptome atlas of the human fetal …
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction
The pancreas and liver arise from a common pool of progenitors. However, the underlying
mechanisms that drive their lineage diversification from the foregut endoderm are not fully …
mechanisms that drive their lineage diversification from the foregut endoderm are not fully …
Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling
To decipher the populations of cells present in the human fetal pancreas and their lineage
relationships, we developed strategies to isolate pancreatic progenitors, endocrine …
relationships, we developed strategies to isolate pancreatic progenitors, endocrine …
TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling
Genetic differences between pluripotent stem cell lines cause variable activity of
extracellular signaling pathways, limiting reproducibility of directed differentiation protocols …
extracellular signaling pathways, limiting reproducibility of directed differentiation protocols …
Concise review: human pluripotent stem cells for the modeling of pancreatic β-cell pathology
D Balboa, J Saarimäki-Vire, T Otonkoski - Stem Cells, 2019 - academic.oup.com
Pancreatic β-cells are the only source of insulin. Disturbances in β-cell development or
function may thus result in insulin deficiency or excess, presenting as hyper-or …
function may thus result in insulin deficiency or excess, presenting as hyper-or …
Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
Cell proliferation is fundamental for almost all stages of development and differentiation that
require an increase in cell number. Although cell cycle phase has been associated with …
require an increase in cell number. Although cell cycle phase has been associated with …
Analysis of differentiation protocols defines a common pancreatic progenitor molecular signature and guides refinement of endocrine differentiation
A Wesolowska-Andersen, RR Jensen, MP Alcántara… - Stem Cell Reports, 2020 - cell.com
Several distinct differentiation protocols for deriving pancreatic progenitors (PPs) from
human pluripotent stem cells have been described, but it remains to be shown how similar …
human pluripotent stem cells have been described, but it remains to be shown how similar …