Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

The protozoans Leishmania and Trypanosoma, belonging to the same Trypanosomatidae
family, are the causative agents of Leishmaniasis, Chagas disease, and human African …

Thioredoxin plays a crucial role in a wide number of physiological processes, which span
from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics …

Infectious diseases caused by trypanosomatids, including African trypanosomiasis (slee**
sickness), Chagas disease, and different forms of leishmaniasis, are Neglected Tropical …

Trypanosomatids are the causative agents of African slee** sickness, Chagas' disease,
and the different forms of leishmaniasis. This family of protozoan parasite possesses a …

All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit
several drawbacks including toxicity, high costs and route of administration. Furthermore …

ABSTRACT A series of new selenocyanates and diselenides bearing interesting bioactive
scaffolds (quinoline, quinoxaline, acridine, chromene, furane, isosazole, etc.) was …

A molecular docking analysis has been carried out to examine potential Leishmania protein
targets of antiprotozoal plant-derived polyphenolic compounds. A total of 352 phenolic …

In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole
unique metabolism, where most enzymes are essential for parasitic survival and infectivity …