Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …
recognition of its significance, immune status monitoring is not implemented in clinical …
Locally sourced: site-specific immune barriers to metastasis
AL Correia - Nature Reviews Immunology, 2023 - nature.com
Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …
take years to manifest themselves clinically or never even surface within a patient's lifetime …
Multi-omics approaches in psychoneuroimmunology and health research: conceptual considerations and methodological recommendations
The field of psychoneuroimmunology (PNI) has grown substantially in both relevance and
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …
host against a wide range of pathogenic threats. Recent advancements in single-cell and …
Improving generalization of machine learning-identified biomarkers using causal modelling with examples from immune receptor diagnostics
Abstract Machine learning is increasingly used to discover diagnostic and prognostic
biomarkers from high-dimensional molecular data. However, a variety of factors related to …
biomarkers from high-dimensional molecular data. However, a variety of factors related to …
The emerging field of cardioimmunology: past, present and foreseeable future
DL Mann - Circulation Research, 2024 - Am Heart Assoc
Over the past 30 years, the field of cardioimmunology has moved from being dismissed as a
field that was chasing an epiphenomenon of little biological consequence to a scientific …
field that was chasing an epiphenomenon of little biological consequence to a scientific …
[HTML][HTML] The mechanobiology of NK cells-'Forcing NK to Sense'target cells
DCP Wong, JL Ding - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …
Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine
Major depressive disorder (MDD) is a recurrent episodic mood disorder that represents the
third leading cause of disability worldwide. In MDD, several factors can simultaneously …
third leading cause of disability worldwide. In MDD, several factors can simultaneously …
Computational methods and biomarker discovery strategies for spatial proteomics: a review in immuno-oncology
Advancements in imaging technologies have revolutionized our ability to deeply profile
pathological tissue architectures, generating large volumes of imaging data with …
pathological tissue architectures, generating large volumes of imaging data with …
Lung T cell response in COVID-19
MH Shakiba, I Gemünd, M Beyer… - Frontiers in …, 2023 - frontiersin.org
The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory
infections worldwide. Insightful data obtained in the last years have shed light on the …
infections worldwide. Insightful data obtained in the last years have shed light on the …