T-cell and thymic development are processes that have been highly conserved throughout
vertebrate evolution. Mammals, birds, reptiles and fish share common molecular signalling …

Chemokines are a superfamily of cytokines responsible for regulating cell migration under
both inflammatory and physiological conditions. CC chemokines are the largest subfamily of …

While the mammalian macrophage phenotypes have been intensively studied in vitro, the
dynamic of their phenotypic polarization has never been investigated in live vertebrates. We …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

The zebrafish is ideal for studying embryogenesis and is increasingly applied to model
human disease. In these contexts, RNA-sequencing (RNA-seq) provides mechanistic …

The transcriptional programs that govern hematopoiesis have been investigated primarily by
population-level analysis of hematopoietic stem and progenitor cells, which cannot reveal …

Background: Macrophages and neutrophils are key phagocytes in regeneration. Results:
Neutrophils are the primary phagocytes in the inflammatory stage and are dispensable for …

Kidney function depends on the nephron, which comprises a blood filter, a tubule that is
subdivided into functionally distinct segments, and a collecting duct. How these regions …

Histone methylation plays an important role in eukaryotic transcriptional regulation. A
number of histone methyltransferases (HMTases) with distinct functions have been …

Mutations in SOX18 cause the human hypotrichosis-lymphedema-telangiectasia (HLT)
syndrome. Their murine counterparts are the spontaneous ragged mutants, showing …