Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Lipids are indispensable for energy storage, membrane structure and cell signalling.
However, dynamic changes in various categories of endogenous lipids in mammalian early …

Cell death is a natural biological process that occurs in living organisms. Since 1963,
extensive research has shed light on the occurrence, progress, and final outcome of cell …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

The sorting and trafficking of lipids between organelles gives rise to a dichotomy of bulk
membrane properties between organelles of the secretory and endolysosome networks …

Phosphoinositides are a family of membrane lipids essential for many biological and
pathological processes. Due to the existence of multiple phosphoinositide regioisomers and …