Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …

Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

Chromosomal instability is a hallmark of cancer that results from ongoing errors in
chromosome segregation during mitosis. Although chromosomal instability is a major driver …

Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …

Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …

Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting
in constitutive activation of the cGAS–STING innate immune pathway. How tumors co-opt …

Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the
presence of extra centrosomes,,,. However, a direct mechanistic link between extra …

Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …