Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

With the ever-increasing demand for lithium (Li) for portable energy storage devices, there is
a global concern associated with environmental contamination of Li, via the production, use …

scribí la primera edición de Fisiología de la Conducta hace más de un cuarto de siglo.
Cuando lo hice no podía imaginarme que algún día estaría escribiendo la octava edición …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …

Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent
teratogen, but its mechanisms of action in any of these settings are unknown. We report that …

Regeneration of large-size bone defects represents a significant challenge clinically, which
requires the use of scaffolds with multifunction, such as anti-bacterial activity, and stimulation …

Abstract Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a
surprisingly large number of cellular processes and diseases. Several mechanisms play a …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Human osteoarthritis is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multifactorial, the cartilage destruction …