The dynamic roles of the inner membrane complex in the multiple stages of the malaria parasite

JL Ferreira, D Heincke, JS Wichers, B Liffner… - Frontiers in Cellular …, 2021 - frontiersin.org
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …

[HTML][HTML] Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies

DT Ouologuem, A Dara, A Kone, A Ouattara… - Microorganisms, 2023 - mdpi.com
Malaria elimination may never succeed without the implementation of transmission-blocking
strategies. The transmission of Plasmodium spp. parasites from the human host to the …

A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium

X Wang, P Qian, H Cui, L Yao, J Yuan - The EMBO journal, 2020 - embopress.org
Morphogenesis of many protozoans depends on a polarized establishment of cytoskeletal
structures. In malaria‐causing parasites, this can be observed when a round zygote …

Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite

P Qian, X Wang, CQ Zhong, J Wang, M Cai… - Elife, 2022 - elifesciences.org
Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …

N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action

AC Schlott, AA Holder, EW Tate - ACS Infectious Diseases, 2018 - ACS Publications
Malaria continues to be a significant cause of death and morbidity worldwide, and there is a
need for new antimalarial drugs with novel targets. We have focused as a potential target for …

Post-translational modifications of proteins of malaria parasites during the life cycle

E Schwarzer, O Skorokhod - International Journal of Molecular Sciences, 2024 - mdpi.com
Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …

Progress toward understanding protein S-acylation: prospective in plants

Y Li, B Qi - Frontiers in Plant Science, 2017 - frontiersin.org
S-acylation, also known as S-palmitoylation or palmitoylation, is a reversible post-
translational lipid modification in which long chain fatty acid, usually the 16-carbon …

Toxoplasma F-box protein 1 is required for daughter cell scaffold function during parasite replication

CG Baptista, A Lis, B Deng, E Gas-Pascual… - PLoS …, 2019 - journals.plos.org
By binding to the adaptor protein SKP1 and serving as substrate receptors for the SKP1
Cullin, F-box E3 ubiquitin ligase complex, F-box proteins regulate critical cellular processes …

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

JS Wichers, J Wunderlich, D Heincke… - Cellular …, 2021 - Wiley Online Library
The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which
confers stability and shape to the cell, functions as a scaffolding compartment during the …

Protein S-palmitoylation in cellular differentiation

MM Zhang, HC Hang - Biochemical Society Transactions, 2017 - portlandpress.com
Reversible protein S-palmitoylation confers spatiotemporal control of protein function by
modulating protein stability, trafficking and activity, as well as protein–protein and membrane …