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The dynamic roles of the inner membrane complex in the multiple stages of the malaria parasite
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …
encompassing multiple and diverse environmental niches. Invading, replicating, and …
[HTML][HTML] Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies
Malaria elimination may never succeed without the implementation of transmission-blocking
strategies. The transmission of Plasmodium spp. parasites from the human host to the …
strategies. The transmission of Plasmodium spp. parasites from the human host to the …
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium
X Wang, P Qian, H Cui, L Yao, J Yuan - The EMBO journal, 2020 - embopress.org
Morphogenesis of many protozoans depends on a polarized establishment of cytoskeletal
structures. In malaria‐causing parasites, this can be observed when a round zygote …
structures. In malaria‐causing parasites, this can be observed when a round zygote …
Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite
Malaria is caused by infection of the erythrocytes by the parasites Plasmodium. Inside the
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …
erythrocytes, the parasites multiply via schizogony, an unconventional cell division mode …
N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action
Malaria continues to be a significant cause of death and morbidity worldwide, and there is a
need for new antimalarial drugs with novel targets. We have focused as a potential target for …
need for new antimalarial drugs with novel targets. We have focused as a potential target for …
Post-translational modifications of proteins of malaria parasites during the life cycle
E Schwarzer, O Skorokhod - International Journal of Molecular Sciences, 2024 - mdpi.com
Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …
influencing various fundamental processes in eukaryotes. These include, but are not limited …
Progress toward understanding protein S-acylation: prospective in plants
Y Li, B Qi - Frontiers in Plant Science, 2017 - frontiersin.org
S-acylation, also known as S-palmitoylation or palmitoylation, is a reversible post-
translational lipid modification in which long chain fatty acid, usually the 16-carbon …
translational lipid modification in which long chain fatty acid, usually the 16-carbon …
Toxoplasma F-box protein 1 is required for daughter cell scaffold function during parasite replication
By binding to the adaptor protein SKP1 and serving as substrate receptors for the SKP1
Cullin, F-box E3 ubiquitin ligase complex, F-box proteins regulate critical cellular processes …
Cullin, F-box E3 ubiquitin ligase complex, F-box proteins regulate critical cellular processes …
Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum
The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which
confers stability and shape to the cell, functions as a scaffolding compartment during the …
confers stability and shape to the cell, functions as a scaffolding compartment during the …
Protein S-palmitoylation in cellular differentiation
MM Zhang, HC Hang - Biochemical Society Transactions, 2017 - portlandpress.com
Reversible protein S-palmitoylation confers spatiotemporal control of protein function by
modulating protein stability, trafficking and activity, as well as protein–protein and membrane …
modulating protein stability, trafficking and activity, as well as protein–protein and membrane …