Brain injury following transient or permanent focal cerebral ischaemia (stroke) develops from
a complex series of pathophysiological events that evolve in time and space. In this article …

Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency that accounts for
5% of all stroke cases. Individuals affected are typically in the prime of their lives (mean age …

Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger
sequential and complex metabolic and cellular pathologies. This leads to brain tissue …

Glutaminase 1 is the main enzyme responsible for glutamate production in mammalian cells.
The roles of macrophage and microglia glutaminases in brain injury, infection, and …

There is an urgent need for improved diagnostics and therapeutics for acute ischemic stroke.
This is the focus of numerous research projects involving in vitro studies, animal models and …

Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix
calcium and is characterized by the opening of the PT pore (PTP). Activation of the PTP …

Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production
can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage …

Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such …

In inflammatory, infectious, ischemic, and neurodegenerative pathologies of th central
nervous system (CNS) glia become “activated” by inflammatory mediators, and express new …