Two different perspectives have informed efforts to explain the link between the brain and
behaviour. One approach seeks to identify neural circuit elements that carry out specific …

Flexibly selecting appropriate actions in response to complex, ever-changing environments
requires both cortical and subcortical regions, which are typically described as participating …

Behavior relies on activity in structured neural circuits that are distributed across the brain,
but most experiments probe neurons in a single area at a time. Using multiple Neuropixels …

Working memory—the brain's ability to internalize information and use it flexibly to guide
behaviour—is an essential component of cognition. Although activity related to working …

The superior colliculus is an evolutionarily conserved midbrain region that is thought to
mediate spatial orienting, including saccadic eye movements and covert spatial attention …

Motor behaviors are often planned long before execution but only released after specific
sensory events. Planning and execution are each associated with distinct patterns of motor …

Neural mechanisms of perceptual decision making have been extensively studied in
experimental settings that mimic stable environments with repeating stimuli, fixed rules, and …

Decision-making requires flexibility to rapidly switch one's actions in response to sensory
stimuli depending on information stored in memory. We identified cortical areas and neural …

A surprising finding of recent studies in mouse is the dominance of widespread movement-
related activity throughout the brain, including in early sensory areas. In awake subjects …

An important problem in systems neuroscience is to identify the latent dynamics underlying
neural population activity. Here we address this problem by introducing a low-dimensional …