Blood biomarkers for Alzheimer's disease in clinical practice and trials

O Hansson, K Blennow, H Zetterberg, J Dage - Nature aging, 2023 - nature.com
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic
work-up of Alzheimer's disease (AD) in clinical practice. This is very timely, considering the …

Develo** the ATX (N) classification for use across the Alzheimer disease continuum

H Hampel, J Cummings, K Blennow, P Gao… - Nature Reviews …, 2021 - nature.com
Breakthroughs in the development of highly accurate fluid and neuroimaging biomarkers
have catalysed the conceptual transformation of Alzheimer disease (AD) from the traditional …

Aducanumab: appropriate use recommendations

J Cummings, P Aisen, LG Apostolova, A Atri… - The journal of …, 2021 - Springer
Aducanumab has been approved by the US Food and Drug Administration for treatment of
Alzheimer's disease (AD). Clinicians require guidance on the appropriate use of this new …

Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration

EH Thijssen, R La Joie, A Wolf, A Strom, P Wang… - Nature medicine, 2020 - nature.com
With the potential development of new disease-modifying Alzheimer's disease (AD)
therapies, simple, widely available screening tests are needed to identify which individuals …

[HTML][HTML] Aducanumab: appropriate use recommendations update

J Cummings, GD Rabinovici, A Atri, P Aisen… - The journal of …, 2022 - Elsevier
Aducanumab (Aduhelm) is approved in the United States for the treatment of patients with
mild cognitive impairment due to Alzheimer's disease or mild AD dementia. Aducanumab …

[HTML][HTML] Current understanding of Alzheimer's disease diagnosis and treatment

J Weller, A Budson - F1000Research, 2018 - ncbi.nlm.nih.gov
Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence
continuing to grow in part because of the aging world population. This neurodegenerative …

Biomarkers for Alzheimer's disease: current status and prospects for the future

K Blennow, H Zetterberg - Journal of internal medicine, 2018 - Wiley Online Library
Accumulating data from the clinical research support that the core Alzheimer's disease (AD)
cerebrospinal fluid (CSF) biomarkers amyloid‐β (Aβ42), total tau (T‐tau), and …

NIA‐AA research framework: toward a biological definition of Alzheimer's disease

CR Jack Jr, DA Bennett, K Blennow… - Alzheimer's & …, 2018 - Wiley Online Library
Abstract In 2011, the National Institute on Aging and Alzheimer's Association created
separate diagnostic recommendations for the preclinical, mild cognitive impairment, and …

Current state of Alzheimer's fluid biomarkers

JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …