Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
SM Lagoumtzi, N Chondrogianni - Free Radical Biology and Medicine, 2021 - Elsevier
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …
environmental factors, characterizing many types of somatic cells. It has been suggested as …
Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
Immune modulation by curcumin: The role of interleukin-10
Cytokines are small secreted proteins released by different types of cells with specific effects
on cellular signaling and communication via binding to their receptors on the cell surface. IL …
on cellular signaling and communication via binding to their receptors on the cell surface. IL …
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …
Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury
Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma
longa (turmeric). This medicinal compound has different biological activities, including …
longa (turmeric). This medicinal compound has different biological activities, including …
Naringenin reduces inflammatory pain in mice
Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …
The interplay between oxidative stress, exercise, and pain in health and disease: potential role of autonomic regulation and epigenetic mechanisms
Oxidative stress can be induced by various stimuli and altered in certain conditions,
including exercise and pain. Although many studies have investigated oxidative stress in …
including exercise and pain. Although many studies have investigated oxidative stress in …
Contribution of Nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages
L Staurengo-Ferrari, S Badaro-Garcia… - Frontiers in …, 2019 - frontiersin.org
Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …
treat painful and inflammatory diseases, there is still a need for effective and potent …
Role of curcumin in the management of pathological pain
J Sun, F Chen, C Braun, YQ Zhou, H Rittner, YK Tian… - Phytomedicine, 2018 - Elsevier
Background: Pathological pain conditions can be triggered after peripheral nerve injury
and/or inflammation. It is a major clinical problem that is poorly treated with available …
and/or inflammation. It is a major clinical problem that is poorly treated with available …
The specialised pro‐resolving lipid mediator maresin 1 reduces inflammatory pain with a long‐lasting analgesic effect
Background and Purpose Maresin 1 (MaR1) is a specialised pro‐resolving lipid mediator
with anti‐inflammatory and analgesic activities. In this study, we addressed the modulation …
with anti‐inflammatory and analgesic activities. In this study, we addressed the modulation …