[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation
Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …
through an autophagy mechanism, thus maintaining mitochondria and intracellular …
Mitophagy in human health, ageing and disease
Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …
Mechanisms of mitophagy
Autophagy not only recycles intracellular components to compensate for nutrient deprivation
but also selectively eliminates organelles to regulate their number and maintain quality …
but also selectively eliminates organelles to regulate their number and maintain quality …
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
GA Calin, C Sevignani, CD Dumitru… - Proceedings of the …, 2004 - National Acad Sciences
A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs).
Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently …
Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently …
[HTML][HTML] Pathological roles of MAPK signaling pathways in human diseases
EK Kim, EJ Choi - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2010 - Elsevier
The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …
Deconvoluting the context-dependent role for autophagy in cancer
E White - Nature reviews cancer, 2012 - nature.com
Autophagy (also known as macroautophagy) captures intracellular components in
autophagosomes and delivers them to lysosomes, where they are degraded and recycled …
autophagosomes and delivers them to lysosomes, where they are degraded and recycled …
The role of PINK1–Parkin in mitochondrial quality control
Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …
Recent insights into the function of autophagy in cancer
Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …
Mitochondria as playmakers of apoptosis, autophagy and senescence
Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …
species. They are responsible for managing cell life and death by a balanced homeostasis …
Mitochondria and the autophagy–inflammation–cell death axis in organismal aging
Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases.
As mitochondria age in our cells, they become progressively inefficient and potentially toxic …
As mitochondria age in our cells, they become progressively inefficient and potentially toxic …