Cancer biomarkers: emerging trends and clinical implications for personalized treatment

A Passaro, M Al Bakir, EG Hamilton, M Diehn, F André… - Cell, 2024 - cell.com
The integration of cancer biomarkers into oncology has revolutionized cancer treatment,
yielding remarkable advancements in cancer therapeutics and the prognosis of cancer …

[HTML][HTML] Liquid biopsy for advanced NSCLC: a consensus statement from the international association for the study of lung cancer

C Rolfo, P Mack, GV Scagliotti, C Aggarwal… - Journal of Thoracic …, 2021 - Elsevier
Although precision medicine has had a mixed impact on the clinical management of patients
with advanced-stage cancer overall, for NSCLC, and more specifically for lung …

Non-viral precision T cell receptor replacement for personalized cell therapy

SP Foy, K Jacoby, DA Bota, T Hunter, Z Pan, E Stawiski… - Nature, 2023 - nature.com
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells,–.
Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …

[HTML][HTML] ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group

J Pascual, G Attard, FC Bidard, G Curigliano… - Annals of …, 2022 - Elsevier
Circulating tumour DNA (ctDNA) assays conducted on plasma are rapidly develo** a
strong evidence base for use in patients with cancer. The European Society for Medical …

A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results

AR Rappaport, C Kyi, M Lane, MG Hart, ML Johnson… - Nature medicine, 2024 - nature.com
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific
neoantigens hold promise for providing long-term clinical benefit to patients with cancer …

ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

T Powles, ZJ Assaf, N Davarpanah, R Banchereau… - Nature, 2021 - nature.com
Minimally invasive approaches to detect residual disease after surgery are needed to
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …

Detection and characterization of lung cancer using cell-free DNA fragmentomes

D Mathios, JS Johansen, S Cristiano, JE Medina… - Nature …, 2021 - nature.com
Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for
cancer detection and intervention. Here, we use a machine learning model for detecting …

Using circulating tumor DNA in colorectal cancer: current and evolving practices

M Malla, JM Loree, PM Kasi, AR Parikh - Journal of Clinical Oncology, 2022 - ascopubs.org
There exists a tremendous opportunity in identifying and determining the appropriate
predictive and prognostic biomarker (s) for risk stratification of patients with colorectal …

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

AJ Widman, M Shah, A Frydendahl, D Halmos… - Nature medicine, 2024 - nature.com
In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through
accurate assessment of minimal residual disease (MRD) and therapeutic response …

Practical recommendations for using ctDNA in clinical decision making

SA Cohen, MC Liu, A Aleshin - Nature, 2023 - nature.com
The continuous improvement in cancer care over the past decade has led to a gradual
decrease in cancer-related deaths. This is largely attributed to improved treatment and …