Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Purpose: Molecular profiling may have prognostic and predictive value, and is increasingly
used in the clinical setting. There are more than a dozen fibroblast growth factor receptor …

Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate
skeletal development. FGF signaling regulates development of the limb bud and formation of …

Autosomal dominant mutations in fibroblast growth factor receptor 3 (FGFR3) cause
achondroplasia (Ach), the most common form of dwarfism in humans, and related …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

In the last ten years, we have made considerable progress in our genetic and molecular
understanding of all aspects of skeletal development, chondrogenesis, joint formation, and …

▪ Abstract Early development of the vertebrate skeleton depends on genes that pattern the
distribution and proliferation of cells from cranial neural crest, sclerotomes, and lateral plate …

In the past few years, our molecular understanding of bone formation has continued to
increase. This review aims to present a comprehensive view of the current state of …

Over the last decade the identification of mutations in the receptors for fibroblast growth
factors (FGFs) has defined essential roles for FGF signaling in both endochondral and …