Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Leukocyte migration into and through tissues is fundamental to normal physiology,
immunopathology and host defence. Leukocyte entry into the central nervous system (CNS) …

This review addresses current knowledge of the molecular trafficking signals involved in the
migration of circulating leukocytes across the highly specialized blood–central nervous …

In the CNS, the transcription factor NF-κB is a key regulator of inflammation and secondary
injury processes. Following trauma or disease, the expression of NF-κB-dependent genes is …

The symptoms, severity, and course of multiple sclerosis (MS) vary among patients, leading
to complex treatment issues. In recent years, research has focused on specific adhesion …

This review focuses on the neurobiology of integrins, pathophysiological roles of integrins in
neuroplasticity and nervous system disorders, and therapeutic implications of integrins as …

Background The autism spectrum encompasses a set of complex multigenic developmental
disorders that severely impact the development of language, non-verbal communication …

Leukocyte trafficking from the blood into the tissues represents a key process during
inflammation and requires multiple steps mediated by adhesion molecules and …

Multiple sclerosis (MS) is a common autoimmune disease of the CNS. Although an
association between MS and inflammatory bowel diseases is observed, the link connecting …

The loss of blood-brain barrier (BBB) integrity in CNS inflammatory responses triggered by
infection and autoimmunity has generally been associated with the development of …