Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes
The past 3 decades have been characterized by an exponential growth in knowledge and
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …
[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …
Recent advances in the molecular pathophysiology of atrial fibrillation
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …
Clinical Spectrum of SCN5A Mutations: Long QT Syndrome, Brugada Syndrome, and Cardiomyopathy
AAM Wilde, AS Amin - JACC: Clinical Electrophysiology, 2018 - jacc.org
SCN5A gene encodes the pore-forming ion-conducting α-subunit of the cardiac sodium
channel (Nav1. 5), which is responsible for the initiation and propagation of action potentials …
channel (Nav1. 5), which is responsible for the initiation and propagation of action potentials …
Epidemiology of atrial fibrillation: geographic/ecological risk factors, age, sex, genetics
Atrial fibrillation (AF) is the most common arrhythmia with ever-increasing public health
impact. 1 Over 50 years of observation in the Framingham Heart Study (FHS), there is a 4 …
impact. 1 Over 50 years of observation in the Framingham Heart Study (FHS), there is a 4 …
European heart rhythm association (EHRA)/heart rhythm society (HRS)/Asia pacific heart rhythm society (APHRS)/latin American heart rhythm society (LAHRS) expert …
Purpose Genetic testing has advanced significantly since the publication of the 2011
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the …
Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome
Z Li, X **, T Wu, X Zhao, W Wang… - Proceedings of the …, 2021 - National Acad Sciences
Nav1. 5 is the primary voltage-gated Na+ (Nav) channel in the heart. Mutations of Nav1. 5
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …
are associated with various cardiac disorders exemplified by the type 3 long QT syndrome …
Meta-analysis of continuous positive airway pressure as a therapy of atrial fibrillation in obstructive sleep apnea
Atrial fibrillation (AF) is a significant health care problem for patients with obstructive sleep
apnea (OSA). Continuous positive airway pressure (CPAP) as a therapy for OSA is …
apnea (OSA). Continuous positive airway pressure (CPAP) as a therapy for OSA is …
Genetics and epigenetics of atrial fibrillation
E Lozano-Velasco, D Franco, A Aranega… - International journal of …, 2020 - mdpi.com
Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting
up to 1% of the general population. Its prevalence exponentially increases with age and …
up to 1% of the general population. Its prevalence exponentially increases with age and …
Cardiac sodium channel Nav1. 5 and interacting proteins: physiology and pathophysiology
H Abriel - Journal of molecular and cellular cardiology, 2010 - Elsevier
The cardiac voltage-gated Na+ channel Nav1. 5 generates the cardiac Na+ current (INa).
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …