Tissue morphogenesis requires the collective, coordinated motion and deformation of a
large number of cells. Vertex model simulations for tissue mechanics have been developed …

The dynamic behavior of epithelial cell sheets plays a central role during numerous
developmental processes. Genetic and imaging studies of epithelial morphogenesis in a …

We introduce an Active Vertex Model (AVM) for cell-resolution studies of the mechanics of
confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail …

The last few decades have witnessed diversified in vitro models to recapitulate the
architecture and function of living organs or tissues and contribute immensely to advances in …

The origin of rigidity in disordered materials is an outstanding open problem in statistical
physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity …

Organogenesis is a self-organizing process of multiple cells in three-dimensional (3D)
space, where macroscopic tissue deformations are robustly regulated by multicellular …

This study demonstrates computational simulations of multicellular deformation coupled with
chemical patterning in the three-dimensional (3D) space. To address these aspects, we …

Neural progenitors exhibit cell cycle–dependent interkinetic nuclear migration (INM) along
the apicobasal axis. Despite recent advances in understanding its underlying molecular …

In biological development, multiple cells cooperate to form tissue morphologies based on
their mechanical interactions; namely active force generation and passive viscoelastic …

Organoids representing a diversity of tissues have recently been created, bridging the gap
between cell culture and experiments performed in vivo. Being small and amenable to …