Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

Background Inspired by nature, the biomimetic approach has been incorporated into drug
nanocarriers for cancer targeted chemotherapy. The nanocarriers are cloaked in cell …

Cell membranes have recently emerged as a new source of materials for molecular delivery
systems. Cell membranes have been extruded or sonicated to make nanoscale vesicles …

A subset of patients with coronavirus disease 2019 (COVID-19) become critically ill,
suffering from severe respiratory problems and also increased rates of thrombosis. The …

The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

Platelets interact with the coagulation system in a multitude of ways, not only during the
phases of thrombus formation, but also in specific areas within a formed thrombus. This …

Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily
secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic …

Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have
been proved to be of vital importance to elucidate the mechanisms of platelet thrombus …

The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

The role of platelets in hemostasis and thrombosis is dependent on a complex balance of
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …