Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth

Y Shao, SC Forster, E Tsaliki, K Vervier, A Strang… - Nature, 2019‏ - nature.com
Immediately after birth, newborn babies experience rapid colonization by microorganisms
from their mothers and the surrounding environment. Diseases in childhood and later in life …

A human gut bacterial genome and culture collection for improved metagenomic analyses

SC Forster, N Kumar, BO Anonye, A Almeida… - Nature …, 2019‏ - nature.com
Understanding gut microbiome functions requires cultivated bacteria for experimental
validation and reference bacterial genome sequences to interpret metagenome datasets …

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

SC Forster, J Liu, N Kumar, EL Gulliver… - Nature …, 2022‏ - nature.com
Mobile genetic elements (MGEs) carrying antibiotic resistance genes (ARGs) disseminate
ARGs when they mobilise into new bacterial hosts. The nature of such horizontal gene …

Breast milk-derived human milk oligosaccharides promote Bifidobacterium interactions within a single ecosystem

MAE Lawson, IJ O'Neill, M Kujawska… - The ISME …, 2020‏ - academic.oup.com
Diet-microbe interactions play an important role in modulating the early-life microbiota, with
Bifidobacterium strains and species dominating the gut of breast-fed infants. Here, we …

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

YI Duan, C Llorente, S Lang, K Brandl, H Chu, L Jiang… - Nature, 2019‏ - nature.com
Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …

Stepwise pathogenic evolution of Mycobacterium abscessus

JM Bryant, KP Brown, S Burbaud, I Everall… - Science, 2021‏ - science.org
INTRODUCTION Nearly all mycobacterial species are free-living environmental
saprophytes. A few, such as Mycobacterium tuberculosis, have evolved to cause …

Evolution and host-specific adaptation of Pseudomonas aeruginosa

A Weimann, AM Dinan, C Ruis, A Bernut, S Pont… - Science, 2024‏ - science.org
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant
infections in people with underlying immunodeficiencies or structural lung diseases such as …

The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional map**

BS Beresford-Jones, SC Forster, MD Stares, G Notley… - Cell host & …, 2022‏ - cell.com
Human health and disease have increasingly been shown to be impacted by the gut
microbiota, and mouse models are essential for investigating these effects. However, the …

Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice

CP Harkins, B Pichon, M Doumith, J Parkhill, H Westh… - Genome biology, 2017‏ - Springer
Background The spread of drug-resistant bacterial pathogens poses a major threat to global
health. It is widely recognised that the widespread use of antibiotics has generated selective …

Culturing of female bladder bacteria reveals an interconnected urogenital microbiota

K Thomas-White, SC Forster, N Kumar… - Nature …, 2018‏ - nature.com
Metagenomic analyses have indicated that the female bladder harbors an indigenous
microbiota. However, there are few cultured reference strains with sequenced genomes …