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Drosophila melanogaster: A platform for anticancer drug discovery and personalized therapies
Cancer is a complex disease whereby multiple genetic aberrations, epigenetic
modifications, metabolic reprogramming, and the microenvironment contribute to the …
modifications, metabolic reprogramming, and the microenvironment contribute to the …
Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment
Cadherin-catenin complexes are integral components of the adherens junctions crucial for
cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to …
cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to …
An amuse-bouche of stem cell regulation: Underlying principles and mechanisms from adult Drosophila intestinal stem cells
Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …
Insect gut regeneration
In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …
Investigating local and systemic intestinal signalling in health and disease with Drosophila
A Medina, K Bellec, S Polcowñuk… - Disease models & …, 2022 - journals.biologists.com
Whole-body health relies on complex inter-organ signalling networks that enable organisms
to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine …
to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine …
[HTML][HTML] Intestinal stem cells and their niches in homeostasis and disease
Tissues such as the intestine harbor stem cells that have remarkable functional plasticity in
response to a dynamic environment. To adapt to the environment, stem cells constantly …
response to a dynamic environment. To adapt to the environment, stem cells constantly …
[HTML][HTML] Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells
L Al Zouabi, M Stefanutti, S Roumeliotis, G Le Meur… - Cell Reports, 2023 - cell.com
During development and aging, genome mutation leading to loss of heterozygosity (LOH)
can uncover recessive phenotypes within tissue compartments. This phenomenon occurs in …
can uncover recessive phenotypes within tissue compartments. This phenomenon occurs in …
[HTML][HTML] Intestinal organoid modeling: bridging the gap from experimental model to clinical translation
T Liu, X Li, H Li, J Qin, H Xu, J Wen, Y He… - Frontiers in …, 2024 - frontiersin.org
The 3D culture of intestinal organoids entails embedding isolated intestinal crypts and bone
marrow mesenchymal stem cells within a growth factor-enriched matrix gel. This process …
marrow mesenchymal stem cells within a growth factor-enriched matrix gel. This process …
A modelling framework for cancer ecology and evolution
Cancer incidence increases rapidly with age, typically as a polynomial. The somatic
mutation theory explains this increase through the waiting time for enough mutations to build …
mutation theory explains this increase through the waiting time for enough mutations to build …
[HTML][HTML] The morphogenetic changes that lead to cell extrusion in development and cell competition
M Tada - Developmental Biology, 2021 - Elsevier
Cell extrusion is a morphogenetic process in which unfit or dying cells are eliminated from
the tissue at the interface with healthy neighbours in homeostasis. This process is also …
the tissue at the interface with healthy neighbours in homeostasis. This process is also …