Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

H Zhou, L Zhu, J Song, G Wang, P Li, W Li, P Luo… - Molecular cancer, 2022 - Springer
Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading
cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by …

Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

K Brennan, K Martin, SP FitzGerald, J O'sullivan… - Scientific reports, 2020 - nature.com
Extracellular vesicles (EVs) are nano-sized vesicles containing nucleic acid and protein
cargo that are released from a multitude of cell types and have gained significant interest as …

Isolation and characterization of exosomes for cancer research

L Zhu, HT Sun, S Wang, SL Huang, Y Zheng… - Journal of hematology & …, 2020 - Springer
Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins,
nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes …

Extracellular vesicles in liquid biopsies as biomarkers for solid tumors

B Irmer, S Chandrabalan, L Maas, A Bleckmann… - Cancers, 2023 - mdpi.com
Simple Summary During the past decade, liquid biopsy-related publications have increased
exponentially, demonstrating the great potential of screening body fluids for diagnosis …

Liquid biopsies, novel approaches and future directions

A Armakolas, M Kotsari, J Koskinas - Cancers, 2023 - mdpi.com
Simple Summary The gold standard for detecting cancer and profiling tumors is tissue
biopsies. Despite this, tissue biopsies have been associated with many limitations leading to …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Recent progress in exosome research: isolation, characterization and clinical applications

X Wang, J **a, L Yang, J Dai, L He - Cancer Gene Therapy, 2023 - nature.com
Exosomes, a kind of nano-vesicles released by various cell types, carry a variety of “cargos”
including proteins, RNAs, DNAs and lipids. There is substantial evidence that exosomes are …

Diagnostic potential of exosomal extracellular vesicles in oncology

M Andre, A Caobi, JS Miles, A Vashist, MA Ruiz… - BMC cancer, 2024 - Springer
Liquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages
of cancer. The fluid from these biopsies contains extracellular vesicles (EVs), such as …