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Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …
system and are the first line of host defense against microbial pathogens by recognizing …
Pathogenesis and virulence of herpes simplex virus
S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …
Toll-like receptors and the control of immunity
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
Human life within a narrow range: The lethal ups and downs of type I interferons
The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …
coronavirus 2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus …
30 years of NF-κB: a blossoming of relevance to human pathobiology
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …
time, it has been found to have a broad role in gene induction in diverse cellular responses …
Assembly and localization of Toll-like receptor signalling complexes
Signal transduction by the Toll-like receptors (TLRs) is central to host defence against many
pathogenic microorganisms and also underlies a large burden of human disease. Thus, the …
pathogenic microorganisms and also underlies a large burden of human disease. Thus, the …
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that
play a central role in host cell recognition and responses to microbial pathogens. TLR …
play a central role in host cell recognition and responses to microbial pathogens. TLR …
IRF and STAT transcription factors-from basic biology to roles in infection, protective immunity, and primary immunodeficiencies
The induction and action of type I interferon (IFN) is of fundamental importance in human
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …