Energy metabolism (encompassing energy assimilation, conversion and utilization) plays a
central role in all life processes and serves as a link between the organismal physiology …

Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …

Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …

Major histocompatibility complex class I (MHC-I) molecules, which are dimers of a
glycosylated polymorphic transmembrane heavy chain and the small-protein β2 …

Abstract N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates
protein expression in various posttranscriptional levels. Functional studies of m6A in …

Glycosylation is one of the most common protein modifications and is essential for cells. This
modification is exceptionally complex because glycans are highly diverse and can be …

Biological aging is the main driver of age‐associated chronic diseases. In 2014, the United
States National Institute of Aging (NIA) sponsored a meeting between several investigators …

Proteinaceous cysteines function as essential sensors of cellular redox state. Consequently,
defining the cysteine redoxome is a key challenge for functional proteomic studies. While …

Protein degradation occurs through proteasomal, endosomal, and lysosomal pathways.
Technological advancements have allowed for the determination of protein copy numbers …