Increasing evidence from animal and in vitro studies indicates that n− 3 fatty acids,
especially the long-chain polyunsaturated fatty acids eicosapentaenoic acid and …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

A New Avenue of Research Beyond Traditional Studies of Vitamin E In the current literature,
more than 95% of all studies of vitamin E are directed toward the specific exploration of the …

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Individual protein kinase C (PKC) isozymes have been implicated in many cellular
responses important in lung health and disease, including permeability, contraction …

W transition (EMT). Importantly, GSK-3 inhibition also stimulates the transcription of Snail, a
repressor of E-cadherin and an inducer of the EMT. We identify NF B as a transcription factor …

Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …

Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute
the largest group of malignant tumors. Colorectal cancer is one of the most common …