Impact of cryopreservation on spermatozoa freeze-thawed traits and relevance OMICS to assess sperm cryo-tolerance in farm animals

IM Khan, Z Cao, H Liu, A Khan, SU Rahman… - Frontiers in Veterinary …, 2021 - frontiersin.org
Sperm cryopreservation is a powerful tool for the livestock breeding program. Several
technical attempts have been made to enhance the efficiency of spermatozoa …

Advances in non-hormonal male contraception targeting sperm motility

NAP Mariani, JV Silva, M Fardilha… - Human Reproduction …, 2023 - academic.oup.com
BACKGROUND The high rates of unintended pregnancy and the ever-growing world
population impose health, economic, social, and environmental threats to countries …

In stallion spermatozoa, superoxide dismutase (cu–Zn)(SOD1) and the Aldo-keto-reductase family 1 member b (AKR1B1) are the proteins most significantly reduced …

G Gaitskell-Phillips, FE Martín-Cano… - Journal of Proteome …, 2021 - ACS Publications
Although cryopreservation is widely used in animal breeding, the technique is still
suboptimal. The population of spermatozoa surviving the procedure experiences changes …

[HTML][HTML] An Accurate and Efficient Approach to Knowledge Extraction from Scientific Publications Using Structured Ontology Models, Graph Neural Networks, and …

TV Ivanisenko, PS Demenkov… - International Journal of …, 2024 - mdpi.com
The rapid growth of biomedical literature makes it challenging for researchers to stay
current. Integrating knowledge from various sources is crucial for studying complex …

Bifenthrin diminishes male fertility potential by inducing protein defects in mouse sperm

JW Bae, JM Hwang, M Yoon, WS Kwon - Toxics, 2024 - mdpi.com
A synthetic pyrethroid pesticide, bifenthrin, has been commonly used as an effective
exterminator, although the rise in its usage has raised concerns regarding its effects on the …

Isoform-specific GSK3A activity is negatively correlated with human sperm motility

MJ Freitas, JV Silva, C Brothag… - MHR: Basic science …, 2019 - academic.oup.com
In mouse and bovine sperm, GSK3 activity is inversely proportional to motility. Targeted
disruption of the GSK3A gene in testis results in normal spermatogenesis, but mature sperm …

First insights on the presence of the unfolded protein response in human spermatozoa

J Santiago, JV Silva, M Fardilha - International journal of molecular …, 2019 - mdpi.com
The unfolded protein response (UPR) is involved in protein quality control and is activated in
response to several stressors. Although in testis the UPR mechanisms are well described …

[PDF][PDF] Multi-omics and male infertility: status, integration and future prospects

A Sinha, V Singh, S Yadav - Front Biosci (Schol Ed), 2017 - article.imrpress.com
Within the cell, gene expression analysis is the key to gain information about different
cellular and physiological events. The multifaceted route of fertilization is a combination of …

[PDF][PDF] ProAKAP4 polypeptide as a biomarker of sperm functionality and male fertility disorders

M Delehedde, S Carracedo, M Selleslagh… - Int. J. Gynecol …, 2019 - researchgate.net
Infertility is nowadays a raising societal problem. An increasing prevalence of male
reproductive disorders, such as testicular cancers, and a global decline in sperm counts …

[HTML][HTML] Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility

JV Silva, MJ Freitas, J Santiago, S Jones… - Fertility and …, 2021 - Elsevier
Objective To design protein phosphatase 1 (PP1)–disrupting peptides covalently coupled to
inert cell-penetrating peptides (CPPs) as sychnologically organized bioportide constructs as …