Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action

LL Burrows - Annual review of microbiology, 2012 - annualreviews.org
Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface
structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis …

Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa

H Huang, X Shao, Y **e, T Wang, Y Zhang… - Nature …, 2019 - nature.com
The virulence of Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is
regulated by many transcriptional factors (TFs) that control the expression of quorum …

A hierarchical cascade of second messengers regulates Pseudomonas aeruginosa surface behaviors

Y Luo, K Zhao, AE Baker, SL Kuchma, KA Coggan… - MBio, 2015 - journals.asm.org
Biofilms are surface-attached multicellular communities. Using single-cell tracking
microscopy, we showed that a pilY1 mutant of Pseudomonas aeruginosa is defective in …

Global regulatory pathways and cross-talk control Pseudomonas aeruginosa environmental lifestyle and virulence phenotype

KA Coggan, MC Wolfgang - Current issues in molecular biology, 2012 - mdpi.com
Pseudomonas aeruginosa is a metabolically versatile environmental bacterium and an
opportunistic human pathogen that relies on numerous signaling pathways to sense …

Sigma factors in Pseudomonas aeruginosa

E Potvin, F Sanschagrin… - FEMS microbiology …, 2008 - academic.oup.com
In Pseudomonas aeruginosa, as in most bacterial species, the expression of genes is tightly
controlled by a repertoire of transcriptional regulators, particularly the so-called sigma (σ) …

Biological roles of cAMP: variations on a theme in the different kingdoms of life

JM Gancedo - Biological Reviews, 2013 - Wiley Online Library
Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

Two-component signal transduction systems: a major strategy for connecting input stimuli to biofilm formation

C Liu, D Sun, J Zhu, W Liu - Frontiers in microbiology, 2019 - frontiersin.org
Biofilms are multicellular communities of microbes that are encased within an extracellular
matrix. Environmental factors induce bacteria to form biofilm. Bacteria have several …

The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity

NB Fulcher, PM Holliday, E Klem, MJ Cann… - Molecular …, 2010 - Wiley Online Library
Multiple virulence systems in the opportunistic pathogen Pseudomonas aeruginosa are
regulated by the second messenger signalling molecule adenosine 3′, 5′‐cyclic …

Surface Sensing for Biofilm Formation in Pseudomonas aeruginosa

CY Chang - Frontiers in microbiology, 2018 - frontiersin.org
Aggregating and forming biofilms on biotic or abiotic surfaces are ubiquitous bacterial
behaviors under various conditions. In clinical settings, persistent presence of biofilms …