Genetic variation, which is generated by mutation, recombination and gene flow, can reduce
the mean fitness of a population, both now and in the future. This 'genetic load'has been …

Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …

Many organisms have sex chromosomes with large nonrecombining regions that have
expanded stepwise, generating “evolutionary strata” of differentiation. The reasons for this …

Linking genetic diversity to extinction is a common goal in genomic studies. Recently, a
debate has arisen regarding the importance of genetic variation in conservation as some …

Next-generation sequencing technology has facilitated the discovery of millions of genetic
variants in human genomes. A sizeable fraction of these variants are predicted to be …

The “cost of domestication” hypothesis posits that the process of domesticating wild species
can result in an increase in the number, frequency, and/or proportion of deleterious genetic …

Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands
of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating …

Intraspecific variation is a major component of biodiversity, yet it has received relatively little
attention from governmental and nongovernmental organizations, especially with regard to …

Now updated for its second edition, Population Genetics is the classic, accessible
introduction to the concepts of population genetics. Combining traditional conceptual …